Assay Detail
Binding
CHEMBL657193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase II
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.74 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23350 | — | — | 1 | 8.96 |
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 8.89 |
| CHEMBL283121 | — | — | 1 | 8.82 |
| CHEMBL23258 | — | — | 1 | 8.82 |
| CHEMBL71872 | — | — | 1 | 8.80 |
| CHEMBL24210 | — | — | 1 | 8.72 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 8.57 |
| CHEMBL69948 | — | — | 1 | 8.54 |
| CHEMBL24120 | — | — | 1 | 8.42 |
| CHEMBL221802 | — | — | 1 | 8.30 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.30 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL122708 | EMATE | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL220493 | — | — | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL302593 | — | — | 1 | 7.82 |
| CHEMBL68590 | — | — | 1 | 7.75 |
| CHEMBL544763 | — | — | 1 | 7.64 |
| CHEMBL71371 | — | — | 1 | 7.57 |
| CHEMBL71549 | — | — | 1 | 7.54 |
| CHEMBL67749 | — | — | 1 | 7.20 |
| CHEMBL68257 | — | — | 1 | 7.12 |
| CHEMBL417287 | — | — | 1 | 7.02 |
| CHEMBL69322 | — | — | 1 | 7.01 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | — | 1 | 6.95 |
| CHEMBL71873 | SULFAMIC ACID PENTACHLOROPHENYL ESTER | — | 1 | 6.90 |
| CHEMBL303601 | — | — | 1 | 6.86 |
| CHEMBL303942 | — | — | 1 | 6.86 |
| CHEMBL24119 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23350 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL24259 | PHENYLSULFAMATE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL283121 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL23258 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL71872 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL24210 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL69948 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL24120 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL221802 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL122708 | EMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL220493 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL302593 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL68590 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL544763 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL71371 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL71549 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL67749 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL68257 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL417287 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL69322 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL71873 | SULFAMIC ACID PENTACHLOROPHENYL ESTER | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL303601 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL303942 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL24119 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL68253 | SULFAMATE | Ki | = | 97000.0 | nM | 4.01 |