Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL657194

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant carbonic anhydrase II (CA2)
ChEMBL ↗
155
Total Activities
155
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT.
J Med Chem (2000) 43 : 4542 -4551
PubMed 11087579 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 155 7.62 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL140110 — — 1 9.70
CHEMBL138253 — — 1 9.52
CHEMBL142132 — — 1 9.52
CHEMBL94836 — — 1 9.52
CHEMBL138920 — — 1 9.40
CHEMBL264879 — — 1 9.30
CHEMBL343916 — — 1 9.30
CHEMBL141753 — — 1 9.30
CHEMBL141899 — — 1 9.30
CHEMBL141624 — — 1 9.30
CHEMBL140792 — — 1 9.22
CHEMBL140095 — — 1 9.22
CHEMBL342026 — — 1 9.22
CHEMBL140481 — — 1 9.15
CHEMBL140616 — — 1 9.15
CHEMBL141351 — — 1 9.05
CHEMBL344156 — — 1 9.05
CHEMBL140370 — — 1 9.00
CHEMBL140805 — — 1 9.00
CHEMBL141168 — — 1 9.00
CHEMBL343048 — — 1 8.82
CHEMBL69149 — — 1 8.82
CHEMBL138603 — — 1 8.82
CHEMBL141868 — — 1 8.70
CHEMBL138847 — — 1 8.70
CHEMBL139946 — — 1 8.70
CHEMBL341760 — — 1 8.70
CHEMBL140879 — — 1 8.70
CHEMBL344034 — — 1 8.70
CHEMBL342610 — — 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL140110 — Ki = 0.2 nM 9.70
CHEMBL138253 — Ki = 0.3 nM 9.52
CHEMBL94836 — Ki = 0.3 nM 9.52
CHEMBL142132 — Ki = 0.3 nM 9.52
CHEMBL138920 — Ki = 0.4 nM 9.40
CHEMBL264879 — Ki = 0.5 nM 9.30
CHEMBL141624 — Ki = 0.5 nM 9.30
CHEMBL141753 — Ki = 0.5 nM 9.30
CHEMBL343916 — Ki = 0.5 nM 9.30
CHEMBL141899 — Ki = 0.5 nM 9.30
CHEMBL342026 — Ki = 0.6 nM 9.22
CHEMBL140095 — Ki = 0.6 nM 9.22
CHEMBL140792 — Ki = 0.6 nM 9.22
CHEMBL140481 — Ki = 0.7 nM 9.15
CHEMBL140616 — Ki = 0.7 nM 9.15
CHEMBL344156 — Ki = 0.9 nM 9.05
CHEMBL141351 — Ki = 0.9 nM 9.05
CHEMBL141168 — Ki = 1.0 nM 9.00
CHEMBL140370 — Ki = 1.0 nM 9.00
CHEMBL140805 — Ki = 1.0 nM 9.00
CHEMBL69149 — Ki = 1.5 nM 8.82
CHEMBL138603 — Ki = 1.5 nM 8.82
CHEMBL343048 — Ki = 1.5 nM 8.82
CHEMBL138847 — Ki = 2.0 nM 8.70
CHEMBL337369 — Ki = 2.0 nM 8.70
CHEMBL344382 — Ki = 2.0 nM 8.70
CHEMBL343046 — Ki = 2.0 nM 8.70
CHEMBL342610 — Ki = 2.0 nM 8.70
CHEMBL139946 — Ki = 2.0 nM 8.70
CHEMBL344034 — Ki = 2.0 nM 8.70
CHEMBL141868 — Ki = 2.0 nM 8.70
CHEMBL140879 — Ki = 2.0 nM 8.70
CHEMBL341760 — Ki = 2.0 nM 8.70
CHEMBL141898 — Ki = 3.0 nM 8.52
CHEMBL138812 — Ki = 3.0 nM 8.52
CHEMBL141756 — Ki = 3.0 nM 8.52
CHEMBL139668 — Ki = 3.0 nM 8.52
CHEMBL140791 — Ki = 3.0 nM 8.52
CHEMBL337328 — Ki = 3.0 nM 8.52
CHEMBL141130 — Ki = 4.0 nM 8.40
CHEMBL262561 — Ki = 5.0 nM 8.30
CHEMBL343098 — Ki = 5.0 nM 8.30
CHEMBL139939 — Ki = 5.0 nM 8.30
CHEMBL141425 — Ki = 6.0 nM 8.22
CHEMBL141108 — Ki = 7.0 nM 8.15
CHEMBL18 ETHOXZOLAMIDE Ki = 8.0 nM 8.10
CHEMBL422825 — Ki = 8.0 nM 8.10
CHEMBL140306 — Ki = 8.0 nM 8.10
CHEMBL344001 — Ki = 8.0 nM 8.10
CHEMBL342407 — Ki = 8.0 nM 8.10