Assay Detail
Binding
CHEMBL657288
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Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.
35
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.09 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336228 | — | — | 2 | 8.74 |
| CHEMBL138499 | — | — | 1 | 8.70 |
| CHEMBL344035 | — | — | 1 | 8.25 |
| CHEMBL134083 | — | — | 1 | 8.17 |
| CHEMBL337090 | — | — | 1 | 8.03 |
| CHEMBL336436 | — | — | 1 | 7.99 |
| CHEMBL138661 | — | — | 1 | 7.92 |
| CHEMBL140506 | — | — | 1 | 7.77 |
| CHEMBL343759 | — | — | 1 | 7.75 |
| CHEMBL343423 | — | — | 1 | 7.54 |
| CHEMBL336458 | — | — | 1 | 7.51 |
| CHEMBL336474 | — | — | 1 | 7.50 |
| CHEMBL141793 | — | — | 1 | 7.45 |
| CHEMBL140606 | — | — | 1 | 7.38 |
| CHEMBL140756 | — | — | 2 | 7.35 |
| CHEMBL342463 | — | — | 1 | 7.33 |
| CHEMBL142118 | — | — | 1 | 7.14 |
| CHEMBL342437 | — | — | 1 | 6.96 |
| CHEMBL139132 | — | — | 1 | 6.92 |
| CHEMBL343957 | — | — | 1 | 6.89 |
| CHEMBL423923 | — | — | 1 | 6.87 |
| CHEMBL140429 | — | — | 1 | 6.86 |
| CHEMBL436604 | — | — | 1 | 6.51 |
| CHEMBL138611 | — | — | 1 | 6.45 |
| CHEMBL342145 | — | — | 1 | 6.30 |
| CHEMBL140824 | — | — | 1 | 6.23 |
| CHEMBL345081 | — | — | 1 | 6.19 |
| CHEMBL138586 | — | — | 1 | 5.72 |
| CHEMBL440347 | — | — | 1 | 5.52 |
| CHEMBL140794 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336228 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL138499 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL336228 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL344035 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL134083 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL337090 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL336436 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL138661 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL140506 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL343759 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL343423 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL336458 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL336474 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL141793 | — | IC50 | = | 35.7 | nM | 7.45 |
| CHEMBL140606 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL140756 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL342463 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL142118 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL140756 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL342437 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL139132 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL343957 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL423923 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL140429 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL436604 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL138611 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL342145 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL140824 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL345081 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL138586 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL440347 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL140794 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL344174 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL138284 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL337111 | — | IC50 | > | 1000.0 | nM | - |