Assay Detail
Binding
CHEMBL657293
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Inhibition of human cathepsin B
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.59 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | — | 1 | 8.03 |
| CHEMBL374508 | E-64 | — | 1 | 7.80 |
| CHEMBL1791004 | — | — | 1 | 7.64 |
| CHEMBL136252 | — | — | 1 | 7.52 |
| CHEMBL1790996 | — | — | 1 | 7.28 |
| CHEMBL132595 | — | — | 1 | 7.19 |
| CHEMBL134494 | — | — | 1 | 7.00 |
| CHEMBL1790999 | — | — | 1 | 6.96 |
| CHEMBL341197 | — | — | 1 | 6.92 |
| CHEMBL1790991 | — | — | 1 | 6.66 |
| CHEMBL1790997 | — | — | 1 | 6.57 |
| CHEMBL1790990 | — | — | 1 | 6.57 |
| CHEMBL1790994 | — | — | 1 | 6.51 |
| CHEMBL1790989 | — | — | 1 | 6.43 |
| CHEMBL1790995 | — | — | 1 | 6.39 |
| CHEMBL1791000 | — | — | 1 | 6.36 |
| CHEMBL1791001 | — | — | 1 | 6.34 |
| CHEMBL334443 | — | — | 1 | 6.32 |
| CHEMBL342189 | — | — | 1 | 6.28 |
| CHEMBL1790998 | — | — | 1 | 6.28 |
| CHEMBL1790992 | — | — | 1 | 6.24 |
| CHEMBL335942 | — | — | 1 | 6.11 |
| CHEMBL336415 | — | — | 1 | 5.89 |
| CHEMBL336591 | — | — | 1 | 5.85 |
| CHEMBL1790993 | — | — | 1 | 5.82 |
| CHEMBL135471 | — | — | 1 | 5.50 |
| CHEMBL334405 | — | — | 1 | 5.41 |
| CHEMBL134565 | — | — | 1 | - |
| CHEMBL341577 | — | — | 1 | - |
| CHEMBL132652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL374508 | E-64 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1791004 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL136252 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1790996 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL132595 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL134494 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1790999 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL341197 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1790991 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1790997 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1790990 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1790994 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1790989 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1790995 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1791000 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1791001 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL334443 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL342189 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1790998 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1790992 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL335942 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL336415 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL336591 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1790993 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL135471 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL334405 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL134565 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL341577 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL132652 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL336748 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL136024 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335007 | — | IC50 | > | 1000.0 | nM | - |