Assay Detail
Functional
CHEMBL657466
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Cytotoxic potency required to inhibit CH1 cell growth by 50%
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CH1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.19 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.58 |
| CHEMBL121823 | — | — | 1 | 6.78 |
| CHEMBL327096 | — | — | 1 | 6.76 |
| CHEMBL123024 | — | — | 1 | 6.47 |
| CHEMBL105362 | — | — | 1 | 6.31 |
| CHEMBL104004 | — | — | 1 | 6.19 |
| CHEMBL125371 | — | — | 1 | 5.92 |
| CHEMBL340343 | — | — | 1 | 5.90 |
| CHEMBL125180 | — | — | 1 | 5.90 |
| CHEMBL124605 | — | — | 1 | 5.90 |
| CHEMBL126010 | — | — | 1 | 5.47 |
| CHEMBL436589 | ACRIDONE | — | 1 | 4.11 |
| CHEMBL122057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 2.65 | nM | 8.58 |
| CHEMBL121823 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL327096 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL123024 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL105362 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL104004 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL125371 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL340343 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL125180 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL124605 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL126010 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL436589 | ACRIDONE | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL122057 | — | IC50 | > | 100000.0 | nM | - |