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Assay Detail

CHEMBL657467

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxic potency against CH1 cell proliferation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CH1
Confidence 1 — Organism
Curated By Expert

Target

CH1 (CHEMBL614455)
Type CELL-LINE
Organism Homo sapiens

Publication

1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.
Antonini I, Polucci P, Jenkins TC, Kelland LR, Menta E, Pescalli N, Stefanska B, Mazerski J, Martelli S.
J Med Chem (1997) 40 : 3749 -3755
PubMed 9371240 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.70 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104900 1 7.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104900 IC50 = 20.0 nM 7.70