Assay Detail
Functional
CHEMBL657468
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Cytotoxicity activity was measured in human ovarian cell line CH1 using sulforhodamine B (SRB) assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CH1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.65 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90901 | — | — | 1 | 5.98 |
| CHEMBL92265 | — | — | 1 | 5.96 |
| CHEMBL423017 | — | — | 1 | 5.95 |
| CHEMBL91398 | — | — | 1 | 5.89 |
| CHEMBL329863 | — | — | 1 | 5.71 |
| CHEMBL89250 | — | — | 1 | 5.50 |
| CHEMBL89977 | — | — | 1 | 5.36 |
| CHEMBL91163 | — | — | 1 | 5.34 |
| CHEMBL91898 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90901 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL92265 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL423017 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL91398 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL329863 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL89250 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL89977 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL91163 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL91898 | — | IC50 | = | 7500.0 | nM | 5.12 |