Assay Detail
Binding
CHEMBL657477
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Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzolactams as non-peptide cholecystokinin receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.58 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445095 | — | — | 1 | 9.55 |
| CHEMBL38404 | — | — | 1 | 9.00 |
| CHEMBL342640 | — | — | 1 | 8.10 |
| CHEMBL354442 | — | — | 1 | 6.99 |
| CHEMBL354040 | — | — | 1 | 6.96 |
| CHEMBL34335 | — | — | 1 | 6.96 |
| CHEMBL355319 | — | — | 1 | 6.82 |
| CHEMBL170293 | — | — | 1 | 6.80 |
| CHEMBL424211 | — | — | 1 | 6.75 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.61 |
| CHEMBL423278 | — | — | 1 | 6.57 |
| CHEMBL168386 | — | — | 1 | 6.19 |
| CHEMBL352939 | — | — | 1 | 6.06 |
| CHEMBL170777 | — | — | 1 | 5.92 |
| CHEMBL171722 | — | — | 1 | 5.66 |
| CHEMBL169807 | — | — | 1 | 5.30 |
| CHEMBL169931 | — | — | 1 | 5.07 |
| CHEMBL169794 | — | — | 1 | 4.89 |
| CHEMBL170068 | — | — | 1 | 4.77 |
| CHEMBL297534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445095 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL38404 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL342640 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL354442 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL354040 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL34335 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL355319 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL170293 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL424211 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL423278 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL168386 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL352939 | — | IC50 | = | 878.0 | nM | 6.06 |
| CHEMBL170777 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL171722 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL169807 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL169931 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL169794 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL170068 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL297534 | — | IC50 | > | 10000.0 | nM | - |