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Assay Detail

CHEMBL657479

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Gastrin/cholecystokinin type B receptor (CHEMBL298)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Biological properties of (R)-4-benzamido-5-oxopentanoic basic derivatives as CCK-antagonists
Makovec F, Mennuni L, Peris W, Revel L, Rovati LC
Bioorg Med Chem Lett (1993) 3 : 861 -866
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.25 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL537171 1 6.22
CHEMBL283820 SPIROGLUMIDE 2.0 1 5.85
CHEMBL536938 1 5.58
CHEMBL169453 1 5.55
CHEMBL169440 1 5.48
CHEMBL169466 1 5.42
CHEMBL9485 1 5.25
CHEMBL368133 1 4.90
CHEMBL539320 1 4.80
CHEMBL168855 1 4.38
CHEMBL537834 1 4.30
CHEMBL557997 1 -
CHEMBL558614 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL537171 IC50 = 600.0 nM 6.22
CHEMBL283820 SPIROGLUMIDE IC50 = 1400.0 nM 5.85
CHEMBL536938 IC50 = 2600.0 nM 5.58
CHEMBL169453 IC50 = 2800.0 nM 5.55
CHEMBL169440 IC50 = 3300.0 nM 5.48
CHEMBL169466 IC50 = 3800.0 nM 5.42
CHEMBL9485 IC50 = 5600.0 nM 5.25
CHEMBL368133 IC50 = 12500.0 nM 4.90
CHEMBL539320 IC50 = 16000.0 nM 4.80
CHEMBL168855 IC50 = 42200.0 nM 4.38
CHEMBL537834 IC50 = 50000.0 nM 4.30
CHEMBL557997 IC50 = 103800.0 nM -
CHEMBL558614 IC50 = 120500.0 nM -