Assay Detail
Binding
CHEMBL657480
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Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.08 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326979 | — | — | 1 | 5.72 |
| CHEMBL111808 | — | — | 1 | 5.51 |
| CHEMBL321811 | — | — | 1 | 5.48 |
| CHEMBL114913 | — | — | 1 | 5.39 |
| CHEMBL112682 | — | — | 1 | 5.38 |
| CHEMBL321265 | — | — | 1 | 5.25 |
| CHEMBL112612 | — | — | 1 | 5.20 |
| CHEMBL115456 | — | — | 1 | 5.13 |
| CHEMBL112622 | — | — | 1 | 5.12 |
| CHEMBL444847 | — | — | 1 | 5.10 |
| CHEMBL114926 | — | — | 1 | 5.04 |
| CHEMBL326975 | — | — | 1 | 5.03 |
| CHEMBL419585 | — | — | 1 | 5.01 |
| CHEMBL419031 | — | — | 1 | 5.00 |
| CHEMBL324760 | — | — | 1 | 5.00 |
| CHEMBL111837 | — | — | 1 | 4.96 |
| CHEMBL115656 | — | — | 1 | 4.92 |
| CHEMBL323854 | — | — | 1 | 4.70 |
| CHEMBL323245 | — | — | 1 | 4.57 |
| CHEMBL324652 | — | — | 1 | 4.00 |
| CHEMBL320976 | — | — | 1 | - |
| CHEMBL325161 | — | — | 1 | - |
| CHEMBL325160 | — | — | 1 | - |
| CHEMBL115093 | — | — | 1 | - |
| CHEMBL267339 | — | — | 1 | - |
| CHEMBL114997 | — | — | 1 | - |
| CHEMBL324022 | — | — | 1 | - |
| CHEMBL325220 | — | — | 1 | - |
| CHEMBL112387 | — | — | 1 | - |
| CHEMBL450883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326979 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL111808 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL321811 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL114913 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL112682 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL321265 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL112612 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL115456 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL112622 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL444847 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL114926 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL326975 | — | IC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL419585 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL419031 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL324760 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL111837 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL115656 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL323854 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL323245 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL324652 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL450883 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114916 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL323249 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL112054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL322031 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL331368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114980 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL113041 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL320976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL112387 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324022 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL114997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL267339 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325161 | — | IC50 | > | 10000.0 | nM | - |