Assay Detail
Binding
CHEMBL657482
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In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
On the significance of the C-terminal primary amide in cholecystokinin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.02 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 9.54 |
| CHEMBL384505 | — | — | 2 | 8.00 |
| CHEMBL265147 | — | — | 1 | 7.28 |
| CHEMBL436690 | — | — | 1 | 7.14 |
| CHEMBL268337 | — | — | 1 | 6.22 |
| CHEMBL414523 | — | — | 1 | 6.16 |
| CHEMBL216527 | — | — | 1 | 6.00 |
| CHEMBL413186 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL384505 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL265147 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL436690 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL384505 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL268337 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL414523 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL216527 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL413186 | — | IC50 | = | 1800.0 | nM | 5.75 |