Assay Detail
Binding
CHEMBL657484
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Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.20 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420783 | L-740093 | — | 1 | 10.00 |
| CHEMBL58699 | — | — | 1 | 9.55 |
| CHEMBL313813 | — | — | 1 | 9.25 |
| CHEMBL79565 | — | — | 1 | 8.92 |
| CHEMBL311061 | — | — | 1 | 8.89 |
| CHEMBL313983 | — | — | 1 | 8.82 |
| CHEMBL83130 | — | — | 1 | 8.62 |
| CHEMBL419663 | — | — | 1 | 7.92 |
| CHEMBL84433 | — | — | 1 | 7.82 |
| CHEMBL314846 | — | — | 1 | 7.75 |
| CHEMBL83591 | — | — | 1 | 7.58 |
| CHEMBL309299 | — | — | 1 | 7.44 |
| CHEMBL313653 | — | — | 1 | 7.39 |
| CHEMBL311638 | — | — | 1 | 7.27 |
| CHEMBL82685 | — | — | 1 | 7.18 |
| CHEMBL315214 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420783 | L-740093 | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL58699 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL313813 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL79565 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL311061 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL313983 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL83130 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL419663 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL84433 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL314846 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL83591 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL309299 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL313653 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL311638 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL82685 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL315214 | — | IC50 | = | 137.0 | nM | 6.86 |