Assay Detail

CHEMBL657561

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Binding

Inhibition of Calcium/calmodulin-dependent protein kinase type II

ChEMBL ↗

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Target

CaM kinase II (CHEMBL2097164) ↗

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Primary target CaM kinase II

CHEMBL2097164

Anchored from Assay target.

Protein identity CaM kinase II

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

CaM kinase II (CHEMBL2097164) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.

Sanchez-Martinez C, Shih C, Faul MM, Zhu G, Paal M, Somoza C, Li T, Kumrich CA, Winneroski LL, Xun Z, Brooks HB, Patel BK, Schultz RM, DeHahn TB, Spencer CD, Watkins SA, Considine E, Dempsey JA, Ogg CA, Campbell RM, Anderson BA, Wagner J.
Bioorg Med Chem Lett (2003) 13 : 3835 -3839
PubMed 14552791 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.68	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL388978	STAUROSPORINE	—	1	8.70
CHEMBL268368	STAUROSPORINE AGLYCON	—	1	7.60
CHEMBL16958	STAUROSPORINONE	—	1	6.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL388978	STAUROSPORINE	IC50	=	2.0	nM	8.70
CHEMBL268368	STAUROSPORINE AGLYCON	IC50	=	25.0	nM	7.60
CHEMBL16958	STAUROSPORINONE	IC50	=	184.0	nM	6.74