Assay Detail
Binding
CHEMBL657565
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Inhibition of Casein kinase I (CK1)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aplidium |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.66 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44545 | MERIDIANIN B | — | 1 | 6.00 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.77 |
| CHEMBL44541 | MERIDIANIN C | — | 1 | 4.52 |
| CHEMBL296682 | MERIDIANIN E | — | 1 | 4.00 |
| CHEMBL46440 | MERIDIANIN D | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44545 | MERIDIANIN B | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL296682 | MERIDIANIN E | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL46440 | MERIDIANIN D | IC50 | = | 100000.0 | nM | 4.00 |