Assay Detail
Functional
CHEMBL657644
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Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular vein
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Jugular vein |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
p-Guanidinobenzoyl-[Hyp3, Thi5, D-Tic7, Oic8]bradykinin is almost completely devoid of the agonist effect of HOE140 on the endothelium-free femoral artery of sheep.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.31 | 9.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437155 | — | — | 1 | 9.58 |
| CHEMBL2028850 | ICATIBANT | 4.0 | 1 | 9.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437155 | — | Kd | = | 0.263 | nM | 9.58 |
| CHEMBL2028850 | ICATIBANT | Kd | = | 0.912 | nM | 9.04 |