Assay Detail
Binding
CHEMBL657846
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Inhibitory activity against human carbonic anhydrase II
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 7.03 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352483 | — | — | 1 | 8.10 |
| CHEMBL171589 | — | — | 1 | 8.05 |
| CHEMBL170592 | — | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL169869 | — | — | 1 | 7.82 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL169188 | — | — | 1 | 7.70 |
| CHEMBL169789 | — | — | 1 | 7.70 |
| CHEMBL352535 | — | — | 1 | 7.68 |
| CHEMBL169684 | — | — | 1 | 7.68 |
| CHEMBL366775 | — | — | 1 | 7.68 |
| CHEMBL171031 | — | — | 1 | 7.52 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL170875 | — | — | 1 | 7.40 |
| CHEMBL168976 | — | — | 1 | 7.38 |
| CHEMBL353514 | — | — | 1 | 7.30 |
| CHEMBL422747 | — | — | 1 | 7.30 |
| CHEMBL170938 | — | — | 1 | 7.30 |
| CHEMBL171350 | — | — | 1 | 7.22 |
| CHEMBL422907 | — | — | 1 | 7.22 |
| CHEMBL169623 | — | — | 1 | 7.21 |
| CHEMBL354626 | — | — | 1 | 7.10 |
| CHEMBL352612 | — | — | 1 | 7.05 |
| CHEMBL355026 | — | — | 1 | 6.99 |
| CHEMBL355320 | — | — | 1 | 6.92 |
| CHEMBL171792 | — | — | 1 | 6.92 |
| CHEMBL170085 | — | — | 1 | 6.82 |
| CHEMBL170588 | — | — | 1 | 6.68 |
| CHEMBL169820 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352483 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL171589 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL170592 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL169869 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL169188 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL169789 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL352535 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL169684 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL366775 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL171031 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL170875 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL168976 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL353514 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL422747 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL170938 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL171350 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL422907 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL169623 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL354626 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL352612 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL355026 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL171792 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL355320 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL170085 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL170588 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL169820 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL169903 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL171095 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL172567 | — | Ki | = | 314.0 | nM | 6.50 |
| CHEMBL168383 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL352768 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL169617 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL353693 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL170151 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL354197 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL354732 | — | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL170145 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL355309 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL168431 | — | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL171221 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL366948 | — | Ki | = | 544.0 | nM | 6.26 |
| CHEMBL171625 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL170041 | — | Ki | = | 595.0 | nM | 6.22 |
| CHEMBL446175 | — | Ki | = | 620.0 | nM | 6.21 |