Assay Detail
Binding
CHEMBL657847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human carbonic anhydrase II (hCA II)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.23 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51668 | — | — | 1 | 8.30 |
| CHEMBL7087 | — | — | 1 | 6.80 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51668 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL414 | CARZENIDE | Ki | = | 260.0 | nM | 6.58 |