Assay Detail
Binding
CHEMBL657848
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Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.35 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268439 | — | — | 1 | 8.70 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL7146 | — | — | 1 | 7.52 |
| CHEMBL266026 | — | — | 1 | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL6724 | — | — | 1 | 7.40 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 7.37 |
| CHEMBL269122 | — | — | 1 | 7.34 |
| CHEMBL6853 | — | — | 1 | 7.22 |
| CHEMBL268177 | — | — | 1 | 7.16 |
| CHEMBL7092 | — | — | 1 | 6.96 |
| CHEMBL7087 | — | — | 1 | 6.80 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.77 |
| CHEMBL6705 | — | — | 1 | 6.53 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL7146 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL266026 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL6724 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL865 | VALDECOXIB | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL269122 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL6853 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL268177 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL7092 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL419 | MAFENIDE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL6705 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |