Assay Detail
Binding
CHEMBL657920
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Inhibitory activity against carbonic anhydrase II
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.17 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 9.74 |
| CHEMBL417975 | SEZOLAMIDE | 2.0 | 1 | 9.27 |
| CHEMBL69114 | — | — | 1 | 9.15 |
| CHEMBL84649 | — | — | 1 | 8.92 |
| CHEMBL120728 | — | — | 1 | 8.92 |
| CHEMBL104754 | — | — | 1 | 8.82 |
| CHEMBL104621 | — | — | 1 | 8.64 |
| CHEMBL333281 | — | — | 1 | 8.59 |
| CHEMBL121137 | — | — | 1 | 8.59 |
| CHEMBL120046 | — | — | 1 | 8.55 |
| CHEMBL121086 | — | — | 1 | 8.52 |
| CHEMBL333520 | — | — | 1 | 8.52 |
| CHEMBL120422 | — | — | 1 | 8.52 |
| CHEMBL121031 | — | — | 1 | 8.49 |
| CHEMBL333193 | — | — | 1 | 8.35 |
| CHEMBL105080 | — | — | 1 | 8.25 |
| CHEMBL120304 | — | — | 1 | 8.15 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.68 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.40 |
| CHEMBL120917 | — | — | 1 | 6.89 |
| CHEMBL331715 | — | — | 1 | 5.42 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218490 | DORZOLAMIDE | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL417975 | SEZOLAMIDE | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL69114 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL84649 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL120728 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL104754 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL104621 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL333281 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL121137 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL120046 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL121086 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL333520 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL120422 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL121031 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL333193 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL105080 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL120304 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL19 | METHAZOLAMIDE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL17 | DICHLORPHENAMIDE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL120917 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL331715 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 47000.0 | nM | 4.33 |