Assay Detail
Binding
CHEMBL657970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.18 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7146 | — | — | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 7.57 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL266026 | — | — | 1 | 7.51 |
| CHEMBL6705 | — | — | 1 | 7.48 |
| CHEMBL7087 | — | — | 1 | 7.48 |
| CHEMBL269122 | — | — | 1 | 7.47 |
| CHEMBL268439 | — | — | 1 | 7.42 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.99 |
| CHEMBL6853 | — | — | 1 | 6.61 |
| CHEMBL7092 | — | — | 1 | 6.58 |
| CHEMBL6724 | — | — | 1 | 6.57 |
| CHEMBL268177 | — | — | 1 | 6.54 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7146 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL865 | VALDECOXIB | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL266026 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL6705 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL7087 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL269122 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL268439 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL419 | MAFENIDE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL6853 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL7092 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL6724 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL268177 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 294.0 | nM | 6.53 |