Assay Detail
Binding
CHEMBL657972
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Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.44 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23350 | — | — | 1 | 7.75 |
| CHEMBL283121 | — | — | 1 | 7.72 |
| CHEMBL24120 | — | — | 1 | 7.64 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL544763 | — | — | 1 | 7.58 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL122708 | EMATE | — | 1 | 7.52 |
| CHEMBL220493 | — | — | 1 | 7.50 |
| CHEMBL71549 | — | — | 1 | 7.50 |
| CHEMBL69948 | — | — | 1 | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL71872 | — | — | 1 | 7.47 |
| CHEMBL23258 | — | — | 1 | 7.44 |
| CHEMBL303942 | — | — | 1 | 7.43 |
| CHEMBL302593 | — | — | 1 | 7.41 |
| CHEMBL71873 | SULFAMIC ACID PENTACHLOROPHENYL ESTER | — | 1 | 7.41 |
| CHEMBL67749 | — | — | 1 | 7.40 |
| CHEMBL24119 | — | — | 1 | 7.39 |
| CHEMBL68257 | — | — | 1 | 7.37 |
| CHEMBL71371 | — | — | 1 | 7.36 |
| CHEMBL68590 | — | — | 1 | 7.35 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | — | 1 | 7.33 |
| CHEMBL417287 | — | — | 1 | 7.30 |
| CHEMBL69322 | — | — | 1 | 7.29 |
| CHEMBL303601 | — | — | 1 | 7.27 |
| CHEMBL221802 | — | — | 1 | 7.24 |
| CHEMBL24210 | — | — | 1 | 7.23 |
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23350 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL283121 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL24120 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL544763 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL122708 | EMATE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL220493 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL71549 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL69948 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL71872 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL23258 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL303942 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL302593 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL71873 | SULFAMIC ACID PENTACHLOROPHENYL ESTER | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL67749 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL24119 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL68257 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL71371 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL68590 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL417287 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL69322 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL303601 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL221802 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL24210 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL24259 | PHENYLSULFAMATE | Ki | = | 63.0 | nM | 7.20 |