Assay Detail
Binding
CHEMBL657992
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Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Asteroidea |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.03 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.70 |
| CHEMBL52387 | (RS)-ROSCOVITINE | — | 1 | 6.19 |
| CHEMBL133342 | (S)-ROSCOVITINE | — | 1 | 6.10 |
| CHEMBL130280 | — | — | 1 | 6.05 |
| CHEMBL86066 | — | — | 1 | 5.70 |
| CHEMBL129977 | — | — | 1 | 5.22 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.22 |
| CHEMBL130681 | — | — | 1 | 5.10 |
| CHEMBL133042 | — | — | 1 | 4.92 |
| CHEMBL131378 | — | — | 1 | 4.77 |
| CHEMBL133213 | — | — | 1 | 4.60 |
| CHEMBL131098 | — | — | 1 | 4.40 |
| CHEMBL337454 | — | — | 1 | 4.40 |
| CHEMBL131695 | — | — | 1 | 4.40 |
| CHEMBL132369 | — | — | 1 | 4.30 |
| CHEMBL131382 | — | — | 1 | 4.19 |
| CHEMBL317398 | — | — | 1 | 4.16 |
| CHEMBL133214 | — | — | 1 | 4.05 |
| CHEMBL131896 | — | — | 1 | - |
| CHEMBL226345 | ADENINE | 3.0 | 1 | - |
| CHEMBL422980 | — | — | 1 | - |
| CHEMBL130306 | — | — | 1 | - |
| CHEMBL133290 | — | — | 1 | - |
| CHEMBL133377 | — | — | 1 | - |
| CHEMBL337161 | — | — | 1 | - |
| CHEMBL330897 | — | — | 1 | - |
| CHEMBL336556 | — | — | 1 | - |
| CHEMBL228862 | 6-BENZYLAMINOPURINE | — | 1 | - |
| CHEMBL334619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL52387 | (RS)-ROSCOVITINE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL133342 | (S)-ROSCOVITINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL130280 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL86066 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL129977 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL130681 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL133042 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL131378 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL133213 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL131098 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL337454 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL131695 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL132369 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL131382 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL317398 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL133214 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL131896 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL226345 | ADENINE | IC50 | = | 200000.0 | nM | - |
| CHEMBL422980 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL130306 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL133290 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL133377 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL337161 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL330897 | — | IC50 | = | 320000.0 | nM | - |
| CHEMBL336556 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL228862 | 6-BENZYLAMINOPURINE | IC50 | = | 200000.0 | nM | - |
| CHEMBL334619 | — | IC50 | > | 500000.0 | nM | - |