Assay Detail
Binding
CHEMBL658011
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA polymerase alpha catalytic subunit (CHEMBL1828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase alpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144215 | — | — | 1 | 9.00 |
| CHEMBL2115349 | — | — | 3 | 5.64 |
| CHEMBL16193 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144215 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2115349 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL16193 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL2115349 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL2115349 | — | Ki | = | 37000.0 | nM | 4.43 |