Assay Detail
Binding
CHEMBL658013
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Effective concentration against DNA polymerase alpha
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase alpha catalytic subunit (CHEMBL1828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.46 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333948 | — | — | 1 | 6.00 |
| CHEMBL29711 | APHIDICOLIN | — | 1 | 5.70 |
| CHEMBL119903 | — | — | 1 | 5.52 |
| CHEMBL331536 | — | — | 1 | 5.52 |
| CHEMBL119540 | — | — | 1 | 5.40 |
| CHEMBL118808 | — | — | 1 | 5.40 |
| CHEMBL440899 | — | — | 1 | 5.30 |
| CHEMBL332188 | — | — | 1 | 5.16 |
| CHEMBL119855 | — | — | 1 | 5.10 |
| CHEMBL334214 | — | — | 1 | - |
| CHEMBL119211 | — | — | 1 | - |
| CHEMBL118970 | — | — | 1 | - |
| CHEMBL331025 | — | — | 1 | - |
| CHEMBL331553 | — | — | 1 | - |
| CHEMBL334229 | — | — | 1 | - |
| CHEMBL119038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333948 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL29711 | APHIDICOLIN | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL119903 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL331536 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119540 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL118808 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL440899 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL332188 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL119855 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL334214 | — | EC50 | = | - | nM | - |
| CHEMBL119211 | — | EC50 | = | - | nM | - |
| CHEMBL118970 | — | EC50 | = | - | nM | - |
| CHEMBL331025 | — | EC50 | = | - | nM | - |
| CHEMBL331553 | — | EC50 | = | - | nM | - |
| CHEMBL334229 | — | EC50 | = | - | nM | - |
| CHEMBL119038 | — | EC50 | = | - | nM | - |