Assay Detail
Binding
CHEMBL658039
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Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 7.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278603 | — | — | 1 | 9.00 |
| CHEMBL23435 | — | — | 1 | 9.00 |
| CHEMBL24473 | — | — | 1 | 8.82 |
| CHEMBL22540 | — | — | 1 | 8.70 |
| CHEMBL286004 | — | — | 1 | 8.70 |
| CHEMBL268439 | — | — | 1 | 8.70 |
| CHEMBL282021 | — | — | 1 | 8.52 |
| CHEMBL1907940 | — | — | 1 | 8.52 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.30 |
| CHEMBL282266 | — | — | 1 | 8.22 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL23922 | — | — | 1 | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL23684 | — | — | 1 | 8.00 |
| CHEMBL23579 | — | — | 1 | 8.00 |
| CHEMBL23174 | — | — | 1 | 8.00 |
| CHEMBL23744 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL23967 | — | — | 1 | 7.89 |
| CHEMBL278295 | — | — | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL281376 | — | — | 1 | 7.82 |
| CHEMBL280417 | — | — | 1 | 7.77 |
| CHEMBL280338 | — | — | 1 | 7.77 |
| CHEMBL23681 | — | — | 1 | 7.55 |
| CHEMBL23559 | — | — | 1 | 7.43 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL23238 | — | — | 1 | 7.40 |
| CHEMBL23796 | — | — | 1 | 7.31 |
| CHEMBL23058 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278603 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL23435 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL24473 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL22540 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL286004 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL268439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL282021 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1907940 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL282266 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL23922 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL23174 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL23579 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL23684 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL23744 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL23967 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL278295 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL281376 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL280338 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL280417 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL23681 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL23559 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL23238 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL23796 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL23058 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL281794 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL23377 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL22374 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL279246 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL24121 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL417648 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL419 | MAFENIDE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL283097 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL23591 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL23285 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL278395 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL25600 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL687 | ACETYLSULFANILAMIDE | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL23417 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |