Assay Detail
Binding
CHEMBL658040
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In vitro inhibitory activity against human carbonic anhydrase II (hCAII)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.86 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307939 | — | — | 1 | 9.15 |
| CHEMBL94341 | — | — | 1 | 8.85 |
| CHEMBL74491 | — | — | 1 | 8.82 |
| CHEMBL75855 | — | — | 1 | 8.68 |
| CHEMBL317890 | — | — | 1 | 8.44 |
| CHEMBL540698 | — | — | 1 | 8.42 |
| CHEMBL316779 | — | — | 1 | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL305726 | — | — | 1 | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL77284 | — | — | 1 | 7.92 |
| CHEMBL265534 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL308631 | — | — | 1 | 7.89 |
| CHEMBL76626 | — | — | 1 | 7.89 |
| CHEMBL319818 | — | — | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL98120 | — | — | 1 | 7.82 |
| CHEMBL306118 | — | — | 1 | 7.82 |
| CHEMBL329956 | — | — | 1 | 7.82 |
| CHEMBL94499 | — | — | 1 | 7.80 |
| CHEMBL76563 | — | — | 1 | 7.80 |
| CHEMBL97694 | — | — | 1 | 7.75 |
| CHEMBL77359 | — | — | 1 | 7.72 |
| CHEMBL76956 | — | — | 1 | 7.68 |
| CHEMBL97425 | — | — | 1 | 7.60 |
| CHEMBL94551 | — | — | 1 | 7.52 |
| CHEMBL75747 | — | — | 1 | 7.42 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL97725 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307939 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL94341 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL74491 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL75855 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL317890 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL540698 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL316779 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL305726 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL77284 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL265534 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL319818 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL76626 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL308631 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL98120 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL329956 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL306118 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL94499 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL76563 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL97694 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL77359 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL76956 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL97425 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL94551 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL75747 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL97725 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL317743 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL309592 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL313873 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL75620 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL94746 | — | Ki | = | 95.0 | nM | 7.02 |