Assay Detail
Binding
CHEMBL658041
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Inhibition constant evaluated for the inhibition of human CA II (Carbonic anhydrase II)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.64 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77402 | — | — | 1 | 9.70 |
| CHEMBL75812 | — | — | 1 | 9.68 |
| CHEMBL264618 | — | — | 1 | 9.59 |
| CHEMBL76206 | — | — | 1 | 9.52 |
| CHEMBL75595 | — | — | 1 | 9.41 |
| CHEMBL307401 | — | — | 1 | 8.94 |
| CHEMBL307402 | — | — | 1 | 8.92 |
| CHEMBL77986 | — | — | 1 | 8.91 |
| CHEMBL420572 | — | — | 1 | 8.86 |
| CHEMBL307259 | — | — | 1 | 8.81 |
| CHEMBL309069 | — | — | 1 | 8.79 |
| CHEMBL268439 | — | — | 1 | 8.69 |
| CHEMBL73929 | — | — | 1 | 8.50 |
| CHEMBL76078 | — | — | 1 | 8.46 |
| CHEMBL263457 | — | — | 1 | 8.43 |
| CHEMBL308820 | — | — | 1 | 8.41 |
| CHEMBL78240 | — | — | 1 | 8.39 |
| CHEMBL309890 | — | — | 1 | 8.34 |
| CHEMBL307838 | — | — | 1 | 8.32 |
| CHEMBL407460 | — | — | 1 | 8.31 |
| CHEMBL77483 | — | — | 1 | 8.30 |
| CHEMBL309578 | — | — | 1 | 8.22 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77402 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL75812 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL264618 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL76206 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL75595 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL307401 | — | Ki | = | 1.14 | nM | 8.94 |
| CHEMBL307402 | — | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL77986 | — | Ki | = | 1.24 | nM | 8.91 |
| CHEMBL420572 | — | Ki | = | 1.37 | nM | 8.86 |
| CHEMBL307259 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL309069 | — | Ki | = | 1.61 | nM | 8.79 |
| CHEMBL268439 | — | Ki | = | 2.04 | nM | 8.69 |
| CHEMBL73929 | — | Ki | = | 3.13 | nM | 8.50 |
| CHEMBL76078 | — | Ki | = | 3.45 | nM | 8.46 |
| CHEMBL263457 | — | Ki | = | 3.74 | nM | 8.43 |
| CHEMBL308820 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL78240 | — | Ki | = | 4.11 | nM | 8.39 |
| CHEMBL309890 | — | Ki | = | 4.62 | nM | 8.34 |
| CHEMBL307838 | — | Ki | = | 4.78 | nM | 8.32 |
| CHEMBL407460 | — | Ki | = | 4.93 | nM | 8.31 |
| CHEMBL77483 | — | Ki | = | 4.95 | nM | 8.30 |
| CHEMBL309578 | — | Ki | = | 5.96 | nM | 8.22 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |