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Assay Detail

CHEMBL658042

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Binding
Inhibitory activity against Human carbonic anhydrase II
ChEMBL ↗
246
Total Activities
242
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Scozzafava A, Menabuoni L, Mincione F, Supuran CT.
J Med Chem (2002) 45 : 1466 -1476
PubMed 11906288 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 246 7.72 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2093094 Al complex — 2 9.70
CHEMBL2093092 Al complex — 2 9.52
CHEMBL1795056 — — 1 9.40
CHEMBL408856 — — 2 9.30
CHEMBL2112274 — — 1 9.30
CHEMBL286586 — — 1 9.30
CHEMBL284354 — — 1 9.30
CHEMBL32848 — — 1 9.30
CHEMBL35186 — — 1 9.22
CHEMBL33478 — — 1 9.22
CHEMBL285516 — — 1 9.22
CHEMBL2093091 Al complex — 2 9.22
CHEMBL34852 — — 1 9.22
CHEMBL1795064 — — 1 9.15
CHEMBL1795060 — — 1 9.15
CHEMBL415466 — — 1 9.10
CHEMBL1795059 — — 1 9.10
CHEMBL286131 — — 1 9.10
CHEMBL34317 — — 1 9.10
CHEMBL1795065 — — 1 9.10
CHEMBL32606 — — 1 9.05
CHEMBL284500 — — 1 9.05
CHEMBL35593 — — 1 9.00
CHEMBL35227 — — 1 9.00
CHEMBL416410 — — 1 9.00
CHEMBL262651 — — 1 9.00
CHEMBL431112 — — 1 9.00
CHEMBL35272 — — 1 8.96
CHEMBL35367 — — 1 8.82
CHEMBL36447 — — 1 8.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2093094 Al complex Ki = 0.2 nM 9.70
CHEMBL2093092 Al complex Ki = 0.3 nM 9.52
CHEMBL1795056 — Ki = 0.4 nM 9.40
CHEMBL284354 — Ki = 0.5 nM 9.30
CHEMBL2112274 — Ki = 0.5 nM 9.30
CHEMBL408856 — Ki = 0.5 nM 9.30
CHEMBL32848 — Ki = 0.5 nM 9.30
CHEMBL286586 — Ki = 0.5 nM 9.30
CHEMBL33478 — Ki = 0.6 nM 9.22
CHEMBL285516 — Ki = 0.6 nM 9.22
CHEMBL34852 — Ki = 0.6 nM 9.22
CHEMBL408856 — Ki = 0.6 nM 9.22
CHEMBL35186 — Ki = 0.6 nM 9.22
CHEMBL2093091 Al complex Ki = 0.6 nM 9.22
CHEMBL1795060 — Ki = 0.7 nM 9.15
CHEMBL2093094 Al complex Ki = 0.7 nM 9.15
CHEMBL1795064 — Ki = 0.7 nM 9.15
CHEMBL286131 — Ki = 0.8 nM 9.10
CHEMBL34317 — Ki = 0.8 nM 9.10
CHEMBL1795065 — Ki = 0.8 nM 9.10
CHEMBL2093092 Al complex Ki = 0.8 nM 9.10
CHEMBL1795059 — Ki = 0.8 nM 9.10
CHEMBL415466 — Ki = 0.8 nM 9.10
CHEMBL32606 — Ki = 0.9 nM 9.05
CHEMBL284500 — Ki = 0.9 nM 9.05
CHEMBL2093091 Al complex Ki = 0.9 nM 9.05
CHEMBL416410 — Ki = 1.0 nM 9.00
CHEMBL431112 — Ki = 1.0 nM 9.00
CHEMBL35593 — Ki = 1.0 nM 9.00
CHEMBL262651 — Ki = 1.0 nM 9.00
CHEMBL35227 — Ki = 1.0 nM 9.00
CHEMBL35272 — Ki = 1.1 nM 8.96
CHEMBL34488 — Ki = 1.5 nM 8.82
CHEMBL35367 — Ki = 1.5 nM 8.82
CHEMBL286108 — Ki = 1.5 nM 8.82
CHEMBL36447 — Ki = 1.5 nM 8.82
CHEMBL414154 — Ki = 1.5 nM 8.82
CHEMBL35421 — Ki = 2.0 nM 8.70
CHEMBL286828 — Ki = 2.0 nM 8.70
CHEMBL34867 — Ki = 2.0 nM 8.70
CHEMBL284061 — Ki = 2.0 nM 8.70
CHEMBL289888 — Ki = 2.0 nM 8.70
CHEMBL34253 — Ki = 2.0 nM 8.70
CHEMBL36252 — Ki = 2.0 nM 8.70
CHEMBL33648 — Ki = 2.0 nM 8.70
CHEMBL34314 — Ki = 2.0 nM 8.70
CHEMBL13646 — Ki = 3.0 nM 8.52
CHEMBL32308 — Ki = 3.0 nM 8.52
CHEMBL35061 — Ki = 3.0 nM 8.52
CHEMBL34710 — Ki = 3.0 nM 8.52