Assay Detail
Binding
CHEMBL658045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.36 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167179 | — | — | 1 | 8.15 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL165878 | — | — | 1 | 7.96 |
| CHEMBL168514 | PHENYLSULFAMIDE | — | 1 | 7.92 |
| CHEMBL353767 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL168778 | — | — | 1 | 7.89 |
| CHEMBL168511 | — | — | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL167048 | — | — | 1 | 7.82 |
| CHEMBL166340 | — | — | 1 | 7.80 |
| CHEMBL166446 | — | — | 1 | 7.77 |
| CHEMBL166708 | — | — | 1 | 7.72 |
| CHEMBL166686 | — | — | 1 | 7.68 |
| CHEMBL354323 | — | — | 1 | 7.68 |
| CHEMBL444608 | — | — | 1 | 7.57 |
| CHEMBL169486 | — | — | 1 | 7.50 |
| CHEMBL168910 | — | — | 1 | 7.44 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL168898 | — | — | 1 | 7.31 |
| CHEMBL168526 | — | — | 1 | 6.91 |
| CHEMBL165939 | — | — | 1 | 6.88 |
| CHEMBL169370 | — | — | 1 | 6.83 |
| CHEMBL170015 | — | — | 1 | 6.83 |
| CHEMBL352592 | — | — | 1 | 6.35 |
| CHEMBL355349 | — | — | 1 | 6.19 |
| CHEMBL355555 | — | — | 1 | 6.05 |
| CHEMBL355001 | SULFAMIDE | — | 1 | 4.09 |
| CHEMBL166788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167179 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL165878 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL168514 | PHENYLSULFAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL353767 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL168778 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL168511 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL167048 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL166340 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL166446 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL166708 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL354323 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL166686 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL444608 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL169486 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL168910 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL168898 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL168526 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL165939 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL169370 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL170015 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL352592 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL355349 | — | Ki | = | 647.0 | nM | 6.19 |
| CHEMBL355555 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL166788 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL355690 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL168408 | — | Ki | > | 100000.0 | nM | - |