Assay Detail
Binding
CHEMBL658046
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Inhibitory effect on human Carbonic anhydrase II
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.63 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108502 | — | — | 1 | 8.92 |
| CHEMBL111216 | — | — | 1 | 8.82 |
| CHEMBL281376 | — | — | 1 | 8.70 |
| CHEMBL109151 | — | — | 1 | 8.40 |
| CHEMBL108380 | — | — | 1 | 8.40 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.30 |
| CHEMBL108982 | — | — | 1 | 8.30 |
| CHEMBL320711 | — | — | 1 | 8.22 |
| CHEMBL326036 | — | — | 1 | 8.15 |
| CHEMBL108381 | — | — | 1 | 8.15 |
| CHEMBL326240 | — | — | 1 | 8.15 |
| CHEMBL23579 | — | — | 1 | 8.05 |
| CHEMBL111504 | — | — | 1 | 8.05 |
| CHEMBL322589 | — | — | 1 | 8.05 |
| CHEMBL419553 | — | — | 1 | 8.00 |
| CHEMBL111336 | — | — | 1 | 8.00 |
| CHEMBL108971 | — | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL324906 | — | — | 1 | 7.58 |
| CHEMBL111360 | — | — | 1 | 7.44 |
| CHEMBL109142 | — | — | 1 | 7.37 |
| CHEMBL108389 | — | — | 1 | 7.35 |
| CHEMBL107989 | — | — | 1 | 7.30 |
| CHEMBL419188 | — | — | 1 | 7.16 |
| CHEMBL111245 | — | — | 1 | 7.08 |
| CHEMBL432626 | — | — | 1 | 7.02 |
| CHEMBL107722 | — | — | 1 | 6.94 |
| CHEMBL109153 | — | — | 1 | 6.66 |
| CHEMBL111074 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108502 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL111216 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL281376 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL109151 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL108380 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL108982 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL320711 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL326036 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL108381 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL326240 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL23579 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL111504 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL322589 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL108971 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL419553 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL111336 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL324906 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL111360 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL109142 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL108389 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL107989 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL419188 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL111245 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL432626 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL107722 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL109153 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL111074 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL325321 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL322581 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL419006 | — | Ki | = | 844.0 | nM | 6.07 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 4300.0 | nM | 5.37 |