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Assay Detail

CHEMBL658052

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Binding
Dissociation constant against human carbonic anhydrase II at 37 degree Centigrade
ChEMBL ↗
95
Total Activities
91
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Benzenesulfonamide-peptide conjugates as probes for secondary binding sites near the active site of carbonic anhydrase
Sigal GB, Whitesides GM
Bioorg Med Chem Lett (1996) 6 : 559 -564
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 95 6.84 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL153748 — — 1 8.30
CHEMBL152298 — — 1 8.05
CHEMBL152471 — — 1 8.05
CHEMBL358443 — — 1 8.05
CHEMBL152094 — — 1 8.00
CHEMBL153278 — — 1 7.89
CHEMBL152479 — — 2 7.85
CHEMBL345486 — — 1 7.82
CHEMBL152089 — — 1 7.77
CHEMBL152487 — — 1 7.77
CHEMBL153639 — — 1 7.66
CHEMBL152824 — — 1 7.57
CHEMBL151186 — — 1 7.28
CHEMBL152020 — — 1 7.19
CHEMBL2371116 — — 1 7.03
CHEMBL2371067 — — 2 7.02
CHEMBL357304 — — 1 7.00
CHEMBL2371111 — — 1 6.92
CHEMBL152541 — — 1 6.92
CHEMBL156886 — — 1 6.89
CHEMBL153214 — — 1 6.89
CHEMBL154755 — — 1 6.89
CHEMBL2371112 — — 1 6.89
CHEMBL152785 — — 1 6.85
CHEMBL2371068 — — 1 6.85
CHEMBL152694 — — 1 6.85
CHEMBL348655 — — 1 6.85
CHEMBL2371065 — — 1 6.85
CHEMBL153367 — — 1 6.85
CHEMBL2371066 — — 1 6.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL153748 — Kd = 5.0 nM 8.30
CHEMBL152298 — Kd = 9.0 nM 8.05
CHEMBL152471 — Kd = 9.0 nM 8.05
CHEMBL358443 — Kd = 9.0 nM 8.05
CHEMBL152094 — Kd = 10.0 nM 8.00
CHEMBL153278 — Kd = 13.0 nM 7.89
CHEMBL152479 — Kd = 14.0 nM 7.85
CHEMBL345486 — Kd = 15.0 nM 7.82
CHEMBL152479 — Kd = 15.0 nM 7.82
CHEMBL152487 — Kd = 17.0 nM 7.77
CHEMBL152089 — Kd = 17.0 nM 7.77
CHEMBL153639 — Kd = 22.0 nM 7.66
CHEMBL152824 — Kd = 27.0 nM 7.57
CHEMBL151186 — Kd = 53.0 nM 7.28
CHEMBL152020 — Kd = 64.0 nM 7.19
CHEMBL2371116 — Kd = 94.0 nM 7.03
CHEMBL2371067 — Kd = 96.0 nM 7.02
CHEMBL357304 — Kd = 100.0 nM 7.00
CHEMBL2371067 — Kd = 99.0 nM 7.00
CHEMBL2371111 — Kd = 120.0 nM 6.92
CHEMBL152541 — Kd = 120.0 nM 6.92
CHEMBL2371112 — Kd = 130.0 nM 6.89
CHEMBL156886 — Kd = 130.0 nM 6.89
CHEMBL153214 — Kd = 130.0 nM 6.89
CHEMBL154755 — Kd = 130.0 nM 6.89
CHEMBL153367 — Kd = 140.0 nM 6.85
CHEMBL2371066 — Kd = 140.0 nM 6.85
CHEMBL348655 — Kd = 140.0 nM 6.85
CHEMBL2371065 — Kd = 140.0 nM 6.85
CHEMBL152694 — Kd = 140.0 nM 6.85
CHEMBL152785 — Kd = 140.0 nM 6.85
CHEMBL2371068 — Kd = 140.0 nM 6.85
CHEMBL152528 — Kd = 150.0 nM 6.82
CHEMBL439824 — Kd = 150.0 nM 6.82
CHEMBL153377 — Kd = 160.0 nM 6.80
CHEMBL2371069 — Kd = 160.0 nM 6.80
CHEMBL152522 — Kd = 160.0 nM 6.80
CHEMBL152515 — Kd = 160.0 nM 6.80
CHEMBL2371063 — Kd = 160.0 nM 6.80
CHEMBL2371094 — Kd = 160.0 nM 6.80
CHEMBL2371113 — Kd = 170.0 nM 6.77
CHEMBL345367 — Kd = 170.0 nM 6.77
CHEMBL2371074 — Kd = 170.0 nM 6.77
CHEMBL2371091 — Kd = 170.0 nM 6.77
CHEMBL2371104 — Kd = 190.0 nM 6.72
CHEMBL153441 — Kd = 190.0 nM 6.72
CHEMBL2371090 — Kd = 190.0 nM 6.72
CHEMBL2371092 — Kd = 200.0 nM 6.70
CHEMBL2371099 — Kd = 210.0 nM 6.68
CHEMBL2371064 — Kd = 210.0 nM 6.68