Assay Detail
Binding
CHEMBL658056
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Binding affinity against human carbonic anhydrase II (hCA -II)
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 65 | 7.19 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48292 | — | — | 1 | 8.52 |
| CHEMBL51668 | — | — | 1 | 8.30 |
| CHEMBL50000 | — | — | 1 | 8.30 |
| CHEMBL51506 | — | — | 1 | 8.15 |
| CHEMBL51346 | — | — | 1 | 8.05 |
| CHEMBL298110 | — | — | 1 | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL50128 | — | — | 1 | 8.00 |
| CHEMBL52227 | — | — | 1 | 8.00 |
| CHEMBL54235 | — | — | 1 | 8.00 |
| CHEMBL53407 | — | — | 1 | 7.96 |
| CHEMBL296390 | — | — | 1 | 7.92 |
| CHEMBL50776 | — | — | 1 | 7.80 |
| CHEMBL51719 | — | — | 1 | 7.68 |
| CHEMBL53607 | — | — | 1 | 7.58 |
| CHEMBL50365 | — | — | 1 | 7.55 |
| CHEMBL295343 | — | — | 1 | 7.52 |
| CHEMBL49182 | — | — | 1 | 7.44 |
| CHEMBL300020 | — | — | 1 | 7.44 |
| CHEMBL52550 | — | — | 1 | 7.42 |
| CHEMBL300265 | — | — | 1 | 7.40 |
| CHEMBL431742 | — | — | 1 | 7.38 |
| CHEMBL49974 | — | — | 1 | 7.37 |
| CHEMBL52375 | — | — | 1 | 7.36 |
| CHEMBL417728 | — | — | 1 | 7.35 |
| CHEMBL2113714 | — | — | 1 | 7.32 |
| CHEMBL50045 | — | — | 1 | 7.30 |
| CHEMBL298755 | — | — | 1 | 7.29 |
| CHEMBL53972 | — | — | 1 | 7.28 |
| CHEMBL49062 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48292 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL51668 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL50000 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL51506 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL51346 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL298110 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL50128 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL52227 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL54235 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL53407 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL296390 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL50776 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL51719 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL53607 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL50365 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL295343 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL49182 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL300020 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL52550 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL300265 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL431742 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL49974 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL52375 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL417728 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL2113714 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL50045 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL298755 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL53972 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL49062 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL445615 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL300436 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL418085 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL50921 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL51200 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL51586 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL50897 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL299160 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL50446 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL51534 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL51385 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL51455 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL50481 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL298132 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL53135 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2113715 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL297706 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL51456 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL299744 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL52542 | — | Ki | = | 250.0 | nM | 6.60 |