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Assay Detail

CHEMBL658061

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Binding
Evaluated for its binding affinity towards Cannabinoid receptor 1 (CB1)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cannabinoid receptor 1 (CHEMBL218)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol.
Singer M, Ryan WJ, Saha B, Martin BR, Razdan RK.
J Med Chem (1998) 41 : 4400 -4407
PubMed 9784115 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.16 9.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL336670 1 9.44
CHEMBL138917 1 9.22
CHEMBL411626 1 9.11
CHEMBL344455 1 9.07
CHEMBL138772 1 8.92
CHEMBL136120 1 8.52
CHEMBL337536 1 8.04
CHEMBL344623 1 7.89
CHEMBL337094 1 7.89
CHEMBL140353 1 7.75
CHEMBL139475 1 7.72
CHEMBL140404 1 7.54
CHEMBL465 DRONABINOL 4.0 1 7.39
CHEMBL336658 1 7.22
CHEMBL138667 1 6.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL336670 Ki = 0.36 nM 9.44
CHEMBL138917 Ki = 0.6 nM 9.22
CHEMBL411626 Ki = 0.77 nM 9.11
CHEMBL344455 Ki = 0.86 nM 9.07
CHEMBL138772 Ki = 1.2 nM 8.92
CHEMBL136120 Ki = 3.0 nM 8.52
CHEMBL337536 Ki = 9.2 nM 8.04
CHEMBL344623 Ki = 13.0 nM 7.89
CHEMBL337094 Ki = 13.0 nM 7.89
CHEMBL140353 Ki = 18.0 nM 7.75
CHEMBL139475 Ki = 19.0 nM 7.72
CHEMBL140404 Ki = 29.0 nM 7.54
CHEMBL465 DRONABINOL Ki = 41.0 nM 7.39
CHEMBL336658 Ki = 60.0 nM 7.22
CHEMBL138667 Ki = 187.0 nM 6.73