Assay Detail
Binding
CHEMBL658107
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Inhibitory activity against human CDK2 (Cyclin dependent kinase 2)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.73 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298445 | — | — | 1 | 8.70 |
| CHEMBL295484 | — | — | 1 | 7.70 |
| CHEMBL431336 | — | — | 1 | 7.52 |
| CHEMBL297412 | — | — | 1 | 7.40 |
| CHEMBL46401 | — | — | 1 | 7.22 |
| CHEMBL47527 | — | — | 1 | 7.22 |
| CHEMBL47590 | — | — | 1 | 7.16 |
| CHEMBL295127 | — | — | 1 | 7.10 |
| CHEMBL432116 | — | — | 1 | 7.00 |
| CHEMBL433068 | — | — | 1 | 7.00 |
| CHEMBL45408 | — | — | 1 | 6.96 |
| CHEMBL44119 | — | — | 1 | 6.96 |
| CHEMBL442957 | — | — | 1 | 6.85 |
| CHEMBL47249 | — | — | 1 | 6.80 |
| CHEMBL46817 | — | — | 1 | 6.66 |
| CHEMBL48109 | — | — | 1 | 6.54 |
| CHEMBL47132 | — | — | 1 | 6.52 |
| CHEMBL47636 | — | — | 1 | 6.40 |
| CHEMBL44712 | — | — | 1 | 6.17 |
| CHEMBL295398 | — | — | 1 | 6.16 |
| CHEMBL46429 | — | — | 1 | 6.10 |
| CHEMBL297447 | — | — | 1 | 5.92 |
| CHEMBL45001 | — | — | 1 | 5.60 |
| CHEMBL47690 | — | — | 1 | 5.39 |
| CHEMBL47302 | — | — | 1 | 5.19 |
| CHEMBL47276 | — | — | 1 | - |
| CHEMBL43828 | — | — | 1 | - |
| CHEMBL409506 | — | — | 1 | - |
| CHEMBL48019 | — | — | 1 | - |
| CHEMBL297614 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298445 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL295484 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL431336 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL297412 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL46401 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL47527 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL47590 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL295127 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL432116 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL433068 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL45408 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL44119 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL442957 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL47249 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL46817 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL48109 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL47132 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL47636 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL44712 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL295398 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL46429 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL297447 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL45001 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL47690 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL47302 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL47276 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL43828 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL409506 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL48019 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL297614 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL296666 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL44063 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL46474 | — | Ki | > | 20000.0 | nM | - |