Assay Detail
Functional
CHEMBL658203
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Effective concentration for inhibition of Cannabinoid receptor 1-mediated adenylyl cyclase activity using African green monkey (COS-7) cells transfected with the cDNA of rat CB1 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.31 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432107 | — | — | 1 | 10.46 |
| CHEMBL111724 | — | — | 1 | 10.25 |
| CHEMBL109393 | — | — | 1 | 9.74 |
| CHEMBL111148 | — | — | 1 | 9.24 |
| CHEMBL111340 | — | — | 1 | 8.62 |
| CHEMBL113230 | — | — | 1 | 8.02 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.96 |
| CHEMBL111702 | — | — | 1 | 7.88 |
| CHEMBL111099 | — | — | 1 | 7.40 |
| CHEMBL109972 | — | — | 1 | 7.24 |
| CHEMBL74415 | CANNABINOL | 3.0 | 1 | 6.92 |
| CHEMBL320408 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432107 | — | EC50 | = | 0.035 | nM | 10.46 |
| CHEMBL111724 | — | EC50 | = | 0.056 | nM | 10.25 |
| CHEMBL109393 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL111148 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL111340 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL113230 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL465 | DRONABINOL | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL111702 | — | EC50 | = | 13.3 | nM | 7.88 |
| CHEMBL111099 | — | EC50 | = | 39.9 | nM | 7.40 |
| CHEMBL109972 | — | EC50 | = | 58.1 | nM | 7.24 |
| CHEMBL74415 | CANNABINOL | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL320408 | — | EC50 | = | 927.0 | nM | 6.03 |