Assay Detail
Functional
CHEMBL658294
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The compound was tested for cytotoxic activity against CH1/Cs cell line(human ovarian carcinoma)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CH1/Cs |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N4-(omega-Aminoalkyl)-1-[(omega-aminoalkyl)amino]-4- acridinecarboxamides: novel, potent, cytotoxic, and DNA-binding agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.62 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104423 | — | — | 1 | 8.30 |
| CHEMBL358134 | — | — | 1 | 7.36 |
| CHEMBL146276 | — | — | 1 | 7.34 |
| CHEMBL145082 | — | — | 1 | 6.96 |
| CHEMBL145428 | — | — | 1 | 6.70 |
| CHEMBL342800 | — | — | 1 | 6.43 |
| CHEMBL1794954 | — | — | 1 | 6.28 |
| CHEMBL9940 | — | — | 1 | 6.28 |
| CHEMBL144470 | — | — | 1 | 5.81 |
| CHEMBL145573 | — | — | 1 | 5.72 |
| CHEMBL144975 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104423 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL358134 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL146276 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL145082 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL145428 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL342800 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL1794954 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL9940 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL144470 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL145573 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL144975 | — | IC50 | = | 2150.0 | nM | 5.67 |