Assay Detail
Binding
CHEMBL658504
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Concentration required for 50% inhibition against Prostaglandin G/H synthase 2 from human
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity of ketoprofen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.55 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75435 | DEXKETOPROFEN | 4.0 | 1 | 7.57 |
| CHEMBL274587 | — | — | 1 | 6.52 |
| CHEMBL74276 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75435 | DEXKETOPROFEN | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL274587 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL74276 | — | IC50 | = | 2800.0 | nM | 5.55 |