Assay Detail
Functional
CHEMBL658554
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Inhibitory activity of compound for AA8 cells to reduce cell density by 50% (exposed to compound for 4 hours)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-AA8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicity and metabolic stability of nitracrine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.11 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127655 | 4-NITROQUINOLINE-1-OXIDE | — | 1 | 9.48 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 9.22 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.97 |
| CHEMBL124006 | — | — | 1 | 8.37 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 7.44 |
| CHEMBL338686 | METHANESULFONIC ACID ETHYL ESTER | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127655 | 4-NITROQUINOLINE-1-OXIDE | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL43 | AMSACRINE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL124006 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL338686 | METHANESULFONIC ACID ETHYL ESTER | IC50 | = | 6800.0 | nM | 5.17 |