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Assay Detail

CHEMBL658683

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Binding
Compound was evaluated for the inhibition of cathepsin D at an enzyme level of 50 ng/mL
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cathepsin D (CHEMBL2581)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D
Whitesitt CA, Simon RL, Reel JK, Sigmund SK, Phillips ML, Kevin Shadle J, Heinz LJ, Koppel GA, Hunden DC, Lifer SL, Berry D, Ray J, Little SP, Xiadong Liu, Marshall WS, Panetta JA
Bioorg Med Chem Lett (1996) 6 : 2157 -2162
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.89 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL68595 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL68595 IC50 = 1300.0 nM 5.89