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Assay Detail

CHEMBL658685

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of cathepsin D.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cathepsin D (CHEMBL2581)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D
Whitesitt CA, Simon RL, Reel JK, Sigmund SK, Phillips ML, Kevin Shadle J, Heinz LJ, Koppel GA, Hunden DC, Lifer SL, Berry D, Ray J, Little SP, Xiadong Liu, Marshall WS, Panetta JA
Bioorg Med Chem Lett (1996) 6 : 2157 -2162
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.59 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL69980 1 6.68
CHEMBL68595 1 6.47
CHEMBL70042 1 6.21
CHEMBL302534 1 6.19
CHEMBL69180 1 6.16
CHEMBL68538 1 6.11
CHEMBL68617 1 6.09
CHEMBL70169 1 5.88
CHEMBL68201 1 5.84
CHEMBL67585 1 5.73
CHEMBL69019 1 5.59
CHEMBL69365 1 5.56
CHEMBL68163 1 5.53
CHEMBL69128 1 5.53
CHEMBL307641 1 5.43
CHEMBL304801 1 5.29
CHEMBL67206 1 5.18
CHEMBL67701 1 5.14
CHEMBL69148 1 5.10
CHEMBL66793 1 5.01
CHEMBL68214 1 4.85
CHEMBL69209 1 4.75
CHEMBL68540 1 4.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL69980 IC50 = 210.0 nM 6.68
CHEMBL68595 IC50 = 340.0 nM 6.47
CHEMBL70042 IC50 = 620.0 nM 6.21
CHEMBL302534 IC50 = 640.0 nM 6.19
CHEMBL69180 IC50 = 690.0 nM 6.16
CHEMBL68538 IC50 = 780.0 nM 6.11
CHEMBL68617 IC50 = 820.0 nM 6.09
CHEMBL70169 IC50 = 1310.0 nM 5.88
CHEMBL68201 IC50 = 1460.0 nM 5.84
CHEMBL67585 IC50 = 1860.0 nM 5.73
CHEMBL69019 IC50 = 2560.0 nM 5.59
CHEMBL69365 IC50 = 2760.0 nM 5.56
CHEMBL68163 IC50 = 2980.0 nM 5.53
CHEMBL69128 IC50 = 2940.0 nM 5.53
CHEMBL307641 IC50 = 3690.0 nM 5.43
CHEMBL304801 IC50 = 5130.0 nM 5.29
CHEMBL67206 IC50 = 6640.0 nM 5.18
CHEMBL67701 IC50 = 7200.0 nM 5.14
CHEMBL69148 IC50 = 7940.0 nM 5.10
CHEMBL66793 IC50 = 9740.0 nM 5.01
CHEMBL68214 IC50 = 14100.0 nM 4.85
CHEMBL69209 IC50 = 17600.0 nM 4.75
CHEMBL68540 IC50 = 48400.0 nM 4.32