Assay Detail
Binding
CHEMBL658729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Application of the three-dimensional structures of protein target molecules in structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.86 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273599 | — | — | 1 | 9.85 |
| CHEMBL415964 | — | — | 1 | 9.77 |
| CHEMBL9688 | — | — | 1 | 9.52 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 9.43 |
| CHEMBL9660 | — | — | 1 | 9.00 |
| CHEMBL475 | N-DESETHYL DORZOLAMIDE | — | 1 | 8.82 |
| CHEMBL273822 | — | — | 1 | 8.73 |
| CHEMBL306510 | — | — | 1 | 7.77 |
| CHEMBL73050 | A-77003 | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273599 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL415964 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL9688 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL9660 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL475 | N-DESETHYL DORZOLAMIDE | Ki | = | 1.52 | nM | 8.82 |
| CHEMBL273822 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL306510 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL73050 | A-77003 | Ki | = | 140.0 | nM | 6.85 |