Assay Detail
Binding
CHEMBL658759
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Displacement of 0.1 nM [3H]pCCK-8 from guinea pig pancreatic membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.26 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.19 |
| CHEMBL384035 | — | — | 1 | 9.03 |
| CHEMBL384731 | — | — | 1 | 5.90 |
| CHEMBL384618 | — | — | 1 | 5.86 |
| CHEMBL440259 | — | — | 1 | 5.81 |
| CHEMBL216831 | — | — | 1 | 5.80 |
| CHEMBL437661 | — | — | 1 | 5.72 |
| CHEMBL386304 | — | — | 1 | 5.70 |
| CHEMBL264273 | — | — | 1 | 5.60 |
| CHEMBL2370588 | — | — | 1 | 5.54 |
| CHEMBL267329 | — | — | 1 | 5.51 |
| CHEMBL266990 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL384035 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL384731 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL384618 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL440259 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL216831 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL437661 | — | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL386304 | — | Ki | = | 1996.0 | nM | 5.70 |
| CHEMBL264273 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2370588 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL267329 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL266990 | — | Ki | = | 3850.0 | nM | 5.42 |