Assay Detail
Binding
CHEMBL658773
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Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.27 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320154 | — | — | 1 | 7.47 |
| CHEMBL420658 | — | — | 1 | 7.28 |
| CHEMBL418987 | — | — | 1 | 7.00 |
| CHEMBL103312 | — | — | 1 | 6.92 |
| CHEMBL322913 | — | — | 1 | 6.80 |
| CHEMBL105132 | — | — | 1 | 6.77 |
| CHEMBL104958 | — | — | 1 | 6.75 |
| CHEMBL102879 | — | — | 1 | 6.64 |
| CHEMBL102862 | — | — | 1 | 6.52 |
| CHEMBL103457 | — | — | 1 | 6.41 |
| CHEMBL105404 | — | — | 1 | 6.39 |
| CHEMBL321800 | — | — | 1 | 6.36 |
| CHEMBL321107 | — | — | 1 | 6.09 |
| CHEMBL103276 | — | — | 1 | 6.05 |
| CHEMBL320886 | — | — | 1 | 6.04 |
| CHEMBL102461 | — | — | 1 | 5.96 |
| CHEMBL105303 | — | — | 1 | 5.82 |
| CHEMBL102526 | — | — | 1 | 5.70 |
| CHEMBL101752 | — | — | 1 | 5.70 |
| CHEMBL105618 | — | — | 1 | 5.47 |
| CHEMBL105527 | — | — | 1 | 5.41 |
| CHEMBL101803 | — | — | 1 | 5.32 |
| CHEMBL320901 | — | — | 1 | 5.24 |
| CHEMBL105153 | — | — | 1 | - |
| CHEMBL102703 | — | — | 1 | - |
| CHEMBL319466 | — | — | 1 | - |
| CHEMBL431812 | — | — | 1 | - |
| CHEMBL319196 | — | — | 1 | - |
| CHEMBL101854 | — | — | 1 | - |
| CHEMBL420098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320154 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL420658 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL418987 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL103312 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL322913 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL105132 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL104958 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL102879 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL102862 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL103457 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL105404 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL321800 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL321107 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL103276 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL320886 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL102461 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL105303 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL102526 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL101752 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL105618 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL105527 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL101803 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL320901 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL105153 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL102703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL319466 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL431812 | — | IC50 | > | 5900.0 | nM | - |
| CHEMBL319196 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL101854 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL420098 | — | IC50 | > | 6900.0 | nM | - |
| CHEMBL323127 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL2111654 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL321072 | — | IC50 | > | 10000.0 | nM | - |