Assay Detail
Binding
CHEMBL658779
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Ability of compound to Inhibit the binding of [125I]BH-CCK-8 to Cholecystokinin receptor in isolated guinea pig brain membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of some partially modified retro-inverso analogues of cholecystokinin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.64 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 9.52 |
| CHEMBL1160501 | — | — | 1 | 8.70 |
| CHEMBL1160492 | — | — | 1 | 8.00 |
| CHEMBL1160500 | — | — | 1 | 7.52 |
| CHEMBL1160486 | — | — | 1 | 7.40 |
| CHEMBL1160499 | — | — | 1 | 7.00 |
| CHEMBL1160488 | — | — | 1 | 7.00 |
| CHEMBL1160485 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1160501 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1160492 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1160500 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1160486 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1160499 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1160488 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1160485 | — | IC50 | = | 1000.0 | nM | 6.00 |