Assay Detail
Binding
CHEMBL658891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat brain synaptosomal membrane preparations.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.59 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432107 | — | — | 1 | 9.72 |
| CHEMBL111724 | — | — | 1 | 8.74 |
| CHEMBL111148 | — | — | 1 | 8.59 |
| CHEMBL109393 | — | — | 1 | 8.48 |
| CHEMBL111340 | — | — | 1 | 8.21 |
| CHEMBL111099 | — | — | 1 | 7.48 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.18 |
| CHEMBL113230 | — | — | 1 | 7.14 |
| CHEMBL109972 | — | — | 1 | 6.72 |
| CHEMBL320408 | — | — | 1 | 6.32 |
| CHEMBL111702 | — | — | 1 | 6.25 |
| CHEMBL109692 | — | — | 1 | 6.22 |
| CHEMBL111308 | — | — | 1 | - |
| CHEMBL109257 | — | — | 1 | - |
| CHEMBL109549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432107 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL111724 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL111148 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL109393 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL111340 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL111099 | — | Ki | = | 33.4 | nM | 7.48 |
| CHEMBL465 | DRONABINOL | Ki | = | 66.5 | nM | 7.18 |
| CHEMBL113230 | — | Ki | = | 72.5 | nM | 7.14 |
| CHEMBL109972 | — | Ki | = | 188.9 | nM | 6.72 |
| CHEMBL320408 | — | Ki | = | 480.6 | nM | 6.32 |
| CHEMBL111702 | — | Ki | = | 556.1 | nM | 6.25 |
| CHEMBL109692 | — | Ki | = | 602.4 | nM | 6.22 |
| CHEMBL111308 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL109257 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL109549 | — | Ki | > | 10000.0 | nM | - |