Assay Detail
Binding
CHEMBL658942
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Inhibition of human carbonic anhydrase II (hCA II)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 7.62 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275565 | — | — | 1 | 9.30 |
| CHEMBL13630 | — | — | 1 | 9.22 |
| CHEMBL13614 | — | — | 1 | 8.85 |
| CHEMBL268439 | — | — | 1 | 8.70 |
| CHEMBL13802 | — | — | 1 | 8.70 |
| CHEMBL13646 | — | — | 1 | 8.52 |
| CHEMBL417986 | — | — | 1 | 8.52 |
| CHEMBL418163 | — | — | 1 | 8.22 |
| CHEMBL269122 | — | — | 1 | 8.22 |
| CHEMBL276869 | — | — | 1 | 8.22 |
| CHEMBL274895 | — | — | 1 | 8.22 |
| CHEMBL13555 | — | — | 1 | 8.15 |
| CHEMBL13975 | — | — | 1 | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL14182 | — | — | 1 | 8.05 |
| CHEMBL266157 | — | — | 1 | 8.00 |
| CHEMBL14198 | — | — | 1 | 7.96 |
| CHEMBL266387 | — | — | 1 | 7.89 |
| CHEMBL13410 | — | — | 1 | 7.82 |
| CHEMBL275091 | — | — | 1 | 7.75 |
| CHEMBL6753 | — | — | 1 | 7.72 |
| CHEMBL269628 | — | — | 1 | 7.55 |
| CHEMBL13966 | — | — | 1 | 7.48 |
| CHEMBL13929 | — | — | 1 | 7.44 |
| CHEMBL6724 | — | — | 1 | 7.40 |
| CHEMBL13981 | — | — | 1 | 7.40 |
| CHEMBL13851 | — | — | 1 | 7.32 |
| CHEMBL418164 | — | — | 1 | 7.32 |
| CHEMBL407995 | — | — | 1 | 7.26 |
| CHEMBL6853 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275565 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL13630 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL13614 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL268439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL13802 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL13646 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL417986 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL418163 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL269122 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL276869 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL274895 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL13555 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL13975 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL14182 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL266157 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL14198 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL266387 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL13410 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL275091 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL6753 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL269628 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL13966 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL13929 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL6724 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL13981 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL13851 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL418164 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL407995 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL6853 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL265674 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL268177 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL266240 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL7092 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL14039 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL419 | MAFENIDE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL6852 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL6705 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL7204 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL13982 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL13541 | — | Ki | = | 790.0 | nM | 6.10 |