Assay Detail
Binding
CHEMBL658943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase II
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.61 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545239 | — | — | 1 | 9.16 |
| CHEMBL1204135 | SEZOLAMIDE HYDROCHLORIDE | -1.0 | 1 | 9.15 |
| CHEMBL543604 | — | — | 1 | 8.96 |
| CHEMBL554854 | — | — | 1 | 8.74 |
| CHEMBL545245 | — | — | 1 | 8.64 |
| CHEMBL554091 | — | — | 1 | 8.43 |
| CHEMBL2092886 | — | — | 1 | 8.21 |
| CHEMBL314569 | — | — | 1 | 8.17 |
| CHEMBL555182 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545239 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL1204135 | SEZOLAMIDE HYDROCHLORIDE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL543604 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL554854 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL545245 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL554091 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL2092886 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL314569 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL555182 | — | Ki | = | 9.3 | nM | 8.03 |