Assay Detail
Binding
CHEMBL659129
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CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From micromolar to nanomolar affinity: a systematic approach to identify the binding site of CGRP at the human calcitonin gene-related peptide 1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 5.44 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264010 | — | — | 1 | 7.54 |
| CHEMBL2371143 | — | — | 1 | 6.84 |
| CHEMBL406459 | — | — | 1 | 6.80 |
| CHEMBL411804 | — | — | 1 | 6.77 |
| CHEMBL429765 | — | — | 1 | 6.70 |
| CHEMBL268539 | — | — | 1 | 6.69 |
| CHEMBL20034 | — | — | 1 | 6.66 |
| CHEMBL407854 | — | — | 1 | 6.55 |
| CHEMBL384581 | — | — | 1 | 6.52 |
| CHEMBL405511 | — | — | 1 | 6.44 |
| CHEMBL274851 | — | — | 1 | 6.33 |
| CHEMBL217867 | — | — | 1 | 6.31 |
| CHEMBL265906 | — | — | 1 | 6.21 |
| CHEMBL2371144 | — | — | 1 | 6.04 |
| CHEMBL216710 | — | — | 1 | 5.92 |
| CHEMBL407774 | — | — | 1 | 5.57 |
| CHEMBL440990 | — | — | 1 | 5.52 |
| CHEMBL407740 | — | — | 1 | 5.52 |
| CHEMBL407401 | — | — | 1 | 5.47 |
| CHEMBL404978 | — | — | 1 | 5.40 |
| CHEMBL269328 | — | — | 1 | 5.37 |
| CHEMBL262749 | — | — | 1 | 5.35 |
| CHEMBL406587 | — | — | 1 | 5.35 |
| CHEMBL411078 | — | — | 1 | 5.32 |
| CHEMBL216101 | — | — | 1 | 5.30 |
| CHEMBL386824 | — | — | 1 | 5.19 |
| CHEMBL415812 | — | — | 1 | 5.16 |
| CHEMBL428096 | — | — | 1 | 5.16 |
| CHEMBL265399 | — | — | 1 | 5.10 |
| CHEMBL275984 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264010 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2371143 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL406459 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL411804 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL429765 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL268539 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL20034 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL407854 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL384581 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL405511 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL274851 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL217867 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL265906 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2371144 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL216710 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL407774 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL440990 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL407740 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL407401 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL404978 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL269328 | — | IC50 | = | 4275.0 | nM | 5.37 |
| CHEMBL262749 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL406587 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL411078 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL216101 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL386824 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL428096 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL415812 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL265399 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL275984 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL407697 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL267137 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL269027 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL409205 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL216229 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL438224 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL267182 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL438008 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL405694 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL376040 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL267406 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3350392 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL404977 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL439085 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL405767 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL262961 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL410450 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL266666 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL410354 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL269517 | — | IC50 | = | 95000.0 | nM | 4.02 |