Assay Detail
Functional
CHEMBL659221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration for cytopathicity of HIV-1RF in CEM-SS cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | HIV-1RF |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 (RF/HAT ISOLATE) (CHEMBL613498) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus type 1 (RF/HAT ISOLATE) |
Publication
The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.99 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107200 | — | — | 1 | 8.89 |
| CHEMBL340869 | — | — | 1 | 8.15 |
| CHEMBL129835 | — | — | 1 | 8.00 |
| CHEMBL294840 | — | — | 1 | 7.89 |
| CHEMBL131761 | — | — | 1 | 7.70 |
| CHEMBL131518 | — | — | 1 | 7.52 |
| CHEMBL132489 | — | — | 1 | 6.70 |
| CHEMBL130316 | — | — | 1 | 6.68 |
| CHEMBL428685 | — | — | 1 | 6.60 |
| CHEMBL133010 | — | — | 1 | 6.42 |
| CHEMBL133772 | — | — | 1 | 6.17 |
| CHEMBL335037 | — | — | 1 | 6.15 |
| CHEMBL133393 | — | — | 1 | 6.12 |
| CHEMBL133685 | — | — | 1 | 6.08 |
| CHEMBL323016 | — | — | 1 | 5.94 |
| CHEMBL133678 | — | — | 1 | 5.91 |
| CHEMBL326205 | — | — | 1 | 5.89 |
| CHEMBL106414 | — | — | 1 | 5.89 |
| CHEMBL107409 | — | — | 1 | 5.89 |
| CHEMBL130336 | — | — | 1 | 5.82 |
| CHEMBL106554 | — | — | 1 | 5.77 |
| CHEMBL134059 | — | — | 1 | 5.72 |
| CHEMBL132790 | — | — | 1 | 5.67 |
| CHEMBL134130 | — | — | 1 | 5.62 |
| CHEMBL336795 | — | — | 1 | 5.40 |
| CHEMBL323259 | — | — | 1 | 5.36 |
| CHEMBL325757 | — | — | 1 | 5.33 |
| CHEMBL130984 | — | — | 1 | 5.28 |
| CHEMBL264639 | — | — | 1 | 5.27 |
| CHEMBL335768 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107200 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL340869 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL129835 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL294840 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL131761 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL131518 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL132489 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL130316 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL428685 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL133010 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL133772 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL335037 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL133393 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL133685 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL323016 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL133678 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL326205 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL106414 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL107409 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL130336 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL106554 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL134059 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL132790 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL134130 | — | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL336795 | — | EC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL323259 | — | EC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL325757 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL130984 | — | EC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL264639 | — | EC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL335768 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL108267 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL58542 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL132690 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL110224 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL110175 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL130041 | — | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL110359 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL130934 | — | EC50 | = | 95400.0 | nM | 4.02 |