Assay Detail
Functional
CHEMBL659574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound was tested against Colon 38 tumor growth cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MC-38 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.86 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41056 | — | — | 1 | 8.29 |
| CHEMBL42159 | — | — | 1 | 8.00 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 7.96 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.18 |
| CHEMBL296190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41056 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL42159 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL296190 | — | IC50 | > | 1.0 | nM | - |